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Some good news in the midst of so much bad

creekguycreekguy Senior MemberPosts: 4,323 Senior Member
edited March 2020 in The Lodge #1

_Obviously can't be sure about these results, but it's good to have some hope. _
The researchers identified a cellular protein that is important for the entry of SARS-CoV-2 into lung cells.

"Our results show that SARS-CoV-2 requires the protease TMPRSS2, which is present in the human body, to enter cells," says Stefan Pöhlmann, head of the Infection Biology Unit at the German Primate Center. "This protease is a potential target for therapeutic intervention."

Promising drug

Since it is known that the drug camostat mesilate inhibits the protease TMPRSS2, the researchers have investigated whether it can also prevent infection with SARS-CoV-2. "We have tested SARS-CoV-2 isolated from a patient and found that camostat mesilate blocks entry of the virus into lung cells," says Markus Hoffmann, the lead author of the study. Camostat mesilate is a drug approved in Japan for use in pancreatic inflammation.

"Our results suggest that camostat mesilate might also protect against COVID-19," says Markus Hoffmann. "This should be investigated in clinical trials."

Also, a preliminary paper from China says "Reinfection could not occur in SARS-CoV-2 infected rhesus macaques" Reinfection has been a worry.

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